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Knee Pain Treatment


When physical therapy, nonpharmacologic therapy, nonsteroidal anti-inflammatory drugs (NSAIDs) or simple analgesics (e.g. acetaminophen) no longer offer adequate knee pain relief, viscosupplementation may be a viable option for patients in the earlier stages of osteoarthritis of the knee.

Viscosupplementation uses an injectable hyaluronate fluid that restores, supplements and maintains the natural lubricating and cushioning functions of synovial fluid in the knee.

Synovial fluid, which is naturally present in many joints, is a cushioning and lubricating agent that ensures that our joints function efficiently and without friction. Synovial fluid degenerates in the early stages of OA. By injecting hyaluronate – a naturally occurring component of synovial fluid – into the knee, viscosupplementation augments the unhealthy synovial fluid and offers comfort.

Viscosupplementation provides a safe, effective and convenient solution for relieving joint pain. Although viscosupplementation products are available in 3-, 4-, and 5-injection treatments, there have been recently introduced single-injection offerings that allow for even greater convenience. This type of knee pain injection can provide relief in many people.

Gel-One Hyaluronate is a safe single-injection viscosupplementation treatment that offers convenient and effective treatment for people in the early stages of osteoarthritis. With an effective treatment volume of only 3mL, Gel-One Hyaluronate is the lowest complete treatment volume viscosupplement available.

When it comes to relieving knee pain, there are many different treatment options. Success varies not only by the individual, but also by what’s causing your knee pain. Care for arthritis knee pain, for example, often involves a combination of treatments. Be sure to consult your doctor to discuss the best treatment plan for you.


Many drugs, prescriptions as well as over-the-counter medications, are used to treat arthritis and control pain. Common medications are aspirin-free pain relievers, anti-inflammatory drugs, corticosteroids, disease modifiers and sleep medications.

Low-impact exercise

Regular exercise, including joint and muscle exercises, is important to improve strength and flexibility. Exercise may lessen pain, increase movement, reduce fatigue, and help you look and feel better. When done properly, exercise will not “wear out” joints or increase osteoarthritis.

Heat/cold therapies

Applying heat or cold over joints may provide short-term relief from pain and stiffness. Cold packs help reduce inflammation and swelling, and may be useful for flare-ups. Heat assists in relaxing muscles and increasing circulation.

Weight management

Weight loss helps to ease pain by reducing stress on your joints. After all, your knees bear the full load of your weight plus everything you carry.

Injections for knee pain

Viscosupplementation by injection of Hyaluronan, a substance produced in natural healthy joints, provides temporary relief from knee pain. Anti-inflammatory corticosteroid injections, typically cortisone, are also used to manage inflammation and pain.

Physical and occupational therapies

Physical therapists can work with you to create a personalized exercise program and show you how to use therapeutic heat and massage. Occupational therapists can introduce you to a variety of beneficial devices, such as those used to elevate chair or toilet-seat height.

Assistive devices

You can protect your knees by using a cane or other walking aid to avoid placing excess stress on them. Shoe inserts called orthotics are designed to support, align and improve the function of your foot. In turn, they may lessen the pressure on your knees.


Different types of braces may help reduce knee pain and improve function and mobility. A “support” brace supports the entire load on your knee, and an “unloader” supports the weight on one side, when only one side of the knee is damaged.


Specific activities to avoid include excessive stair climbing; impact-loading sports such as jogging, downhill skiing, and high-impact aerobics; physical exercise involving quick stop-start motion, twisting, or impact stresses; excessive bending and kneeling; lifting or pushing heavy objects; and sitting on low seating surfaces and chairs. When avoidance is not possible, try alternating periods of activity with periods of rest, so your joints don’t become fatigued from the stress of repeated tasks.

Mental health

Talking about your feelings with family members and friends, doing mental exercises such as meditations, staying positive and joining local support groups, can help you better manage your knee pain.

Nontraditional and alternative knee pain treatments

Since herbal and dietary supplements are not regulated by the FDA, and the effectiveness of these treatments is not widely supported by accepted scientific research, it is extremely important for you to consult with your physician about all supplements and medications that you’re taking or are considering.

Early intervention surgery

Debridement, cartilage repair/replacement, meniscus repair/replacement, bone grafts and cell therapy treatment each represent an early-stage treatment option.

Partial Joint Replacement

Partial joint replacement (PJR), also called unicompartmental knee arthroplasty, is appropriate only for severe stages of osteoarthritis of the knee and when the previous suggestions have failed to yield sufficient results. PJR hosts some key advantages to a total joint replacement. It requires a smaller incision and has a shorter recovery time; however, only osteoarthritis confined to a limited area of the knee is suitable for PJR.

Total Joint Replacement

Total joint replacement (TJR) is similar to PJR in that the most damaged areas of cartilage are removed and their surfaces replaced by a prosthesis. Rather than replacing only a confined area of the joint, TJR supplants the entire knee joint. Therefore, total joint replacement inherently requires a larger incision and longer recovery time. This procedure is reserved for very severe cases of OA.

Revision Joint Replacement

When an implant reaches the end of its lifetime, becomes infected or is malpositioned, revision joint replacement may be necessary. During this procedure, a surgeon will replace all prostheses that are affected. Unfortunately, the results are less predictable than a PJR or TJR.


The most invasive and severe of osteoarthritis treatments, the knee segmental procedure is an option for patients who suffer from severe bone loss associated with disease, trauma or revision. The operation generally replaces various parts of the femur and the entire knee joint. A knee segmental procedure is reserved for specific cases requiring advanced resection and restoration.

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Gel-One® is a registered trademark of Seikagaku Corporation.